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Mohammed Majrashi

2 papers in the library · publishing 2018

Papers

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Dopaminergic neurotoxic effects of 3-TFMPP derivatives.

Life Sciences September 15, 2018 Mohammed Majrashi, Mohammed Almaghrabi, Maali Fadan et al.

Designer drugs are synthetically formulated to mimic the psychostimulatory effects of an original controlled/illegal drug of abuse. Designer drugs have similar chemical structure or functional analog as compared to existing controlled psychostimulatory drugs. There is a substantial rise in the production and use of designer drugs globally. Piperazine designer drugs were synthesized as an...

DOI: 10.1016/j.lfs.2018.07.052 (opens in new tab) Full text (opens in new tab) Designer drugs Dopamine Mechanisms of toxicity Neurotoxicity +2

Comparing the dopaminergic neurotoxic effects of benzylpiperazine and benzoylpiperazine.

Toxicology mechanisms and methods March 2018 Daniel P Katz, Mohammed Majrashi, Sindhu Ramesh et al.

Benzylpiperazine has been designated as Schedule I substance under the Controlled Substances Act by Drug Enforcement Administration. Benzylpiperazine is a piperazine derivative, elevates both dopamine and serotonin extracellular levels producing stimulatory and hallucinogenic effects, respectively, similar to methylenedioxymethamphetamine (MDMA). However, the comparative neurotoxic effects of...

DOI: 10.1080/15376516.2017.1376024 (opens in new tab) Full text (opens in new tab) Piperazine designer drugs Apoptosis Mitochondrial functions Monoamine neurotransmission +1