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C Randall Clark

2 papers in the library · publishing 2018-2020

Papers

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Structure fragmentation studies of ring-substituted N-trifluoroacetyl-N-benzylphenethylamines related to the NBOMe drugs.

Rapid Communications in Mass Spectrometry February 28, 2020 Ahmad J. Almalki, C Randall Clark, Jack DeRuiter

The halogenated derivatives of N-(2-methoxy)benzyl-2,5-dimethoxyphenethylamine (25-NBOMe) such as the 4-bromo analogue (25B-NBOMe) represent a new class of hallucinogenic or psychedelic drugs. The purpose of this study was to determine the role of the electron-donating groups (halogen and dimethoxy) in the pathway of decomposition for the distonic molecular radical cation in the electron...

Comparing the dopaminergic neurotoxic effects of benzylpiperazine and benzoylpiperazine.

Toxicology mechanisms and methods March 2018 Daniel P Katz, Mohammed Majrashi, Sindhu Ramesh et al.

Benzylpiperazine has been designated as Schedule I substance under the Controlled Substances Act by Drug Enforcement Administration. Benzylpiperazine is a piperazine derivative, elevates both dopamine and serotonin extracellular levels producing stimulatory and hallucinogenic effects, respectively, similar to methylenedioxymethamphetamine (MDMA). However, the comparative neurotoxic effects of...

DOI: 10.1080/15376516.2017.1376024 (opens in new tab) Full text (opens in new tab) Piperazine designer drugs Apoptosis Mitochondrial functions Monoamine neurotransmission +1