C W Harley

The effects of arousal on apical amplification and conscious state.

Neuroscience of Consciousness September 11, 2016 W A Phillips, M E Larkum, C W Harley et al.

Neocortical pyramidal cells can integrate two classes of input separately and use one to modulate response to the other. Their tuft dendrites are electrotonically separated from basal dendrites and soma by the apical dendrite, and apical hyperpolarization-activated currents (Ih) further isolate subthreshold integration of tuft inputs. When apical depolarization exceeds a threshold, however, it...