Zhengwu Peng

2 papers in the library · 9 citations · publishing 2024-2026

Papers

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CB1R-dependent mitochondrial biogenesis may contribute to the antidepressant effects of esketamine in a chronic variable stress male mouse model.

Neuroscience July 27, 2026 Wei Zhao, Xinxin Zhao, Yunyun Zhang et al.

Major depressive disorder (MDD) is a leading cause of disability worldwide, and current antidepressants are limited by delayed onset and incomplete efficacy. Esketamine produces antidepressant effects more rapidly than conventional treatments, but its underlying mechanisms remain unclear. We examined whether cannabinoid type 1 receptor (CB1R) signaling is associated with hippocampal...

DOI: 10.1016/j.neuroscience.2026.07.059 Full text Esketamine Cb1 receptor Chronic variable stress Hippocampus +1

Effects of esketamine and fluoxetine on depression-like behaviors in chronic variable stress: a role of plasma inflammatory factors.

Frontiers in Psychiatry 2024 Haixia Chen, Xinxin Zhao, Xinxu Ma et al. 9 citations

Mounting evidence has identified the rapid and sustained antidepressive and anxiolytic-like effects of esketamine. However, the underlying mechanism of this no-monoamine target rapid-onset antidepressant is still underexplored. Immune-inflammatory pathways and cell-mediated immune activation, mainly including inflammatory cytokines in plasma, play a pivotal role in the pathogenesis of major...

DOI: 10.3389/fpsyt.2024.1388946 Full text Esketamine Major depressive disorder Chronic variable stress Fluoxetine +6