Δ9 -Tetrahydrocannabinol self-administration induces cell type-specific adaptations in the nucleus accumbens core.
Addiction Biology August 2023 Constanza Garcia-Keller, Madeline Hohmeister, Kailyn Seidling et al.
Drugs of abuse induce cell type-specific adaptations in D1- and D2-medium spiny neurons (MSNs) in the nucleus accumbens core (NAcore) that can bias signalling towards D1-MSNs and enhance relapse vulnerability. Whether Δ9 -tetrahydrocannabinol (THC) use initiates similar neuroadaptations is unknown. D1- and D2-Cre transgenic rats were transfected with Cre-dependent reporters and trained to...
DOI: 10.1111/adb.13286 (opens in new tab)
Full text (opens in new tab)
Addiction
Synaptic plasticity
Cannabinoid receptor 1
Medium spiny neurons
+2