Daniela Neuhofer

2 papers in the library · publishing 2018-2020

Papers

Sort Most recent Most cited

The loss of NMDAR-dependent LTD following cannabinoid self-administration is restored by positive allosteric modulation of CB1 receptors.

Addiction Biology November 2020 Daniela Neuhofer, Sade M Spencer, Vivian C Chioma et al.

Glutamatergic plasticity in the nucleus accumbens core (NAcore) is a key neuronal process in appetitive learning and contributes to pathologies such as drug addiction. Understanding how this plasticity factors into cannabis addiction and relapse has been hampered by the lack of a rodent model of cannabis self-administration. We used intravenous self-administration of two constituents of...

DOI: 10.1111/adb.12843 Full text Addiction Synaptic plasticity Cannabinoids

A Model of Δ9-Tetrahydrocannabinol Self-administration and Reinstatement That Alters Synaptic Plasticity in Nucleus Accumbens.

Biological Psychiatry October 15, 2018 Sade Spencer, Daniela Neuhofer, Vivian C Chioma et al.

Cannabis is the most widely used illicit drug, but knowledge of the neurological consequences of cannabis use is deficient. Two primary components of cannabis are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). We established a THC+CBD model of self-administration and reinstated drug seeking to determine if, similar to other addictive drugs, cannabis produces enduring synaptic changes in...

DOI: 10.1016/j.biopsych.2018.04.016 Full text Cannabidiol Synaptic plasticity Drug abuse Nucleus accumbens +2