Emilio Ambrosio

2 papers in the library · publishing 2018-2021

Papers

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Δ 9-Tetrahydrocannabinol During Adolescence Reprograms the Nucleus Accumbens Transcriptome, Affecting Reward Processing, Impulsivity, and Specific Aspects of Cocaine Addiction-Like Behavior in a Sex-Dependent Manner.

The International Journal of Neuropsychopharmacology November 12, 2021 Javier Orihuel, Roberto Capellán, David Roura-Martínez et al.

Cannabis exposure during adolescence is associated with emotional and motivational alterations that may entail an enhanced risk of developing psychiatric disorders. In rodent models, exposure to cannabinoids during adolescence leads to increased self-administration of opiates and cocaine, however, the psychological and neural mechanisms and the sex-specificity of this phenomenon are largely...

DOI: 10.1093/ijnp/pyab058 Full text Cannabis Rnaseq Cocaine Reward

Selective effects of Δ9-tetrahydrocannabinol on medium spiny neurons in the striatum.

PLoS One 2018 Mónica R Fernández-Cabrera, Alejandro Higuera-Matas, Isabel Fernaud-Espinosa et al.

Derivatives from the Cannabis plant are the most commonly abused illegal substances in the world. The main psychoactive component found in the plant, Δ-9-tetrahydrocannabinol (THC), exerts its effects through the endocannabinoid system. Manipulations of this system affect some types of learning that seem to be dependent on dorsal striatum synaptic plasticity. Dendritic spines exhibit important...

DOI: 10.1371/journal.pone.0200950 Full text