A Model of Δ9-Tetrahydrocannabinol Self-administration and Reinstatement That Alters Synaptic Plasticity in Nucleus Accumbens.
Biological Psychiatry October 15, 2018 Sade Spencer, Daniela Neuhofer, Vivian C Chioma et al.
Cannabis is the most widely used illicit drug, but knowledge of the neurological consequences of cannabis use is deficient. Two primary components of cannabis are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). We established a THC+CBD model of self-administration and reinstated drug seeking to determine if, similar to other addictive drugs, cannabis produces enduring synaptic changes in...
DOI: 10.1016/j.biopsych.2018.04.016 (opens in new tab)
Full text (opens in new tab)
Cannabidiol
Synaptic plasticity
Drug abuse
Nucleus accumbens
+2