Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in schizophrenia: Analyses in patients and in perinatal Δ9-tetrahydrocannabinol-exposed rats.
Pharmacological Research February 2021 Martina di Bartolomeo, Tibor Stark, Oriana Maria Maurel et al.
Perinatal exposure to Δ9-tetrahydrocannabinol (THC) affects brain development and might increase the incidence of psychopathology later in life, which seems to be related to a dysregulation of endocannabinoid and/or dopaminergic systems. We here evaluated the transcriptional regulation of the genes encoding for the cannabinoid CB1 receptor (Cnr1) and the dopamine D2 receptor (Drd2) in perinatal...
DOI: 10.1016/j.phrs.2020.105357 (opens in new tab)
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Cannabidiol
THC
Cannabinoid cb1 receptor
Dna methylation
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