Research SquareJuly 7, 2026Ioanna Spanou, Efstratios Karavasilis, Foteini Christidi et al.
preprint
Abstract Background Migraine patients are prone to nocebo responses, that hinder treatment adherence. Identifying neurobiological markers of nocebo proneness could help predict and mitigate these adverse effects. Methods This prospective three-arm randomized explorative trial examined default mode network (DMN) connectivity changes during the interictal state and an anxiety-induced nocebo...