Michael N. Smolka

2 papers in the library · 100 citations · publishing 2019-2023

Papers

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Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation.

Psychological Medicine April 1, 2023 Laurent Elkrief, Bochao Lin, Mattia Marchi et al.

It has not yet been determined if the commonly reported cannabis-psychosis association is limited to individuals with pre-existing genetic risk for psychotic disorders. We examined whether the relationship between polygenic risk score for schizophrenia (PRS-Sz) and psychotic-like experiences (PLEs), as measured by the Community Assessment of Psychic Experiences-42 (CAPE-42) questionnaire, is...

DOI: 10.1017/s0033291721003378 Full text Cannabis Polygenic risk score Psychosis risk Psychotic-like experience

Grey Matter Volume Differences Associated with Extremely Low Levels of Cannabis Use in Adolescence

Journal of Neuroscience January 14, 2019 Catherine Orr, Philip A. Spechler, Zhipeng Cao et al. 100 citations

Rates of cannabis use among adolescents are high, and are increasing concurrent with changes in the legal status of marijuana and societal attitudes regarding its use. Recreational cannabis use is understudied, especially in the adolescent period when neural maturation may make users particularly vulnerable to the effects of Δ-9-tetrahydrocannabinol (THC) on brain structure. In the current...

DOI: 10.1523/jneurosci.3375-17.2018 Full text