Hanna Lu

2 papers in the library · 6 citations · publishing 2024-2025

Papers

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Transcriptional Signatures of Mitochondrial Metabolism Predict Esketamine-Induced rACC Structural Changes in Adolescent Major Depression.

Journal of the American Academy of Child & Adolescent Psychiatry December 31, 2025 Yanling Zhou, Weicheng Li, Xiaofeng Lan et al.

Objective: To investigate neurobiological mechanisms through which esketamine produces rapid antidepressant effects in adolescents with major depressive disorder (MDD), focusing on structural changes in the rostral anterior cingulate cortex (rACC) and associated molecular pathways. Method: A total of 49 adolescents (13-18 years of age) with DSM-5 MDD were randomized to receive intravenous...

DOI: 10.1016/j.jaac.2025.12.011 Esketamine Adolescent depression Transcriptomics Mitochondrial metabolism +1

Non-improvement predicts subsequent non-response to repeated-dose intravenous ketamine for depression: a re-analysis of a 2-week open-label study in patients with unipolar and bipolar depression.

Translational Psychiatry August 6, 2024 Chengyu Wang, Xiaofeng Lan, Weijian Liu et al. 6 citations

There is insufficient evidence to guide dose and frequency optimization with repeated-dose ketamine for depression. This study assessed the value of symptomatic non-improvement after the first few ketamine infusions as a predictor of overall non-response in depression for early decision-making to discontinue treatment. A total of 135 individuals with major depressive disorder or bipolar...

DOI: 10.1038/s41398-024-03027-2 Full text Depression treatment Ketamine therapy Mental health research Treatment response prediction