Sex-specific effects of psychedelics on prepulse inhibition of startle in 129S6/SvEv mice
Psychopharmacology August 4, 2021 Hiba Z. Vohra, J. Saunders, Alaina M. Jaster et al.
Prepulse inhibition (PPI) of startle is a sensorimotor gating phenomenon perturbed in a variety of neuropsychiatric conditions. Psychedelics disrupt PPI in rats and humans, but their effects and involvement of the serotonin 5-HT2A receptor (5-HT2AR) in mice remain unexplored. We tested the effect of the psychedelic 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) (0.5 mg/kg, i.p.) on startle...