Fully automated head-twitch detection system for the study of 5-HT2A receptor pharmacology in vivo
Scientific Reports October 3, 2019 Mario de la Fuente Revenga, Jong M. Shin, Hiba Z. Vohra et al. 57 citations
Abstract Head-twitch behavior (HTR) is the behavioral signature of psychedelic drugs upon stimulation of the serotonin 5-HT 2A receptor (5-HT 2A R) in rodents. Following the previous report of a semi-automated detection of HTR based on the dynamics of mouse’s head movement, here we present a system for the identification of individual HTR events in a fully automated fashion. The validity of...
DOI: 10.1038/s41598-019-49913-4 (opens in new tab)
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Agonist
Metabotropic glutamate receptor
Metabotropic receptor
Pharmacology