Weidan Pu

Altered glucose metabolism in default mode network and prefrontal circuit in patients with Kallmann syndrome

EJNMMI Research July 11, 2025 Chun-Qing Zhou, Xueying Wang, Mei-Chao Men et al.

This study delineates brain metabolic signatures underlying neuroendocrine-psychosocial interactions in Kallmann syndrome (KS), a rare genetic disorder characterized by congenital hypogonadism and anosmia. In this prospective case-control study, 30 KS patients and 30 matched healthy controls (HCs) underwent brain [18F]FDG PET scans, sex hormone assays, and standardized neuropsychological...