Xing Liu

2 papers in the library · 3 citations · publishing 2021-2024

Papers

The impact of ketamine on emergency rapid sequence intubation: a systematic review and meta-analysis.

BMC emergency medicine September 27, 2024 Qinxue Hu, Xing Liu, Tao Xu et al. 3 citations

Ketamine compared with other sedatives during rapid sequence intubation (RSI) in critically ill patients shows no significant difference in in-hospital mortality, physiological function, or adverse events. A systematic review and meta-analysis of 15 studies (5 randomized controlled trials and 10 cohort studies) involving 16,807 participants found no overall mortality benefit (odds ratio 0.90, 95% confidence interval 0.72 to 1.12). Low-quality evidence suggests ketamine may reduce mortality within the first seven days of hospitalization (odds ratio 0.42, 95% confidence interval 0.19 to 0.93) but may also prolong intensive care unit stay (mean difference -0.71 days free of ICU at day 28, 95% confidence interval -1.38 to -0.05).

DOI: 10.1186/s12873-024-01094-8 Full text Ketamine Mortality Rapid sequence intubation Resuscitation +5

Ketamine ameliorates depressive-like behaviors in mice through increasing glucose uptake regulated by the ERK/GLUT3 signaling pathway

Scientific Reports September 13, 2021 Xin-ping Ouyang, Zhengjia Wang, Mei Luo et al.

Ketamine increased glucose uptake and GLUT3 expression in the prefrontal cortex of female mice with depressive-like behaviors, and this effect depended on activation of the ERK signaling pathway. Mice treated with ketamine showed higher glucose uptake, more lactate production, and shorter immobility time compared to untreated depressed mice. An ERK1/2 inhibitor blocked these ketamine-induced changes, indicating that the ERK/GLUT3 pathway mediates ketamine's antidepressant-like effects on brain energy metabolism.

DOI: 10.1038/s41598-021-97758-7 Full text Medicine