Ketamine ameliorates depressive-like behaviors in mice through increasing glucose uptake regulated by the ERK/GLUT3 signaling pathway
Scientific Reports September 13, 2021 Xin-ping Ouyang, Zhengjia Wang, Mei Luo et al.
Ketamine increased glucose uptake and GLUT3 expression in the prefrontal cortex of female mice with depressive-like behaviors, and this effect depended on activation of the ERK signaling pathway. Mice treated with ketamine showed higher glucose uptake, more lactate production, and shorter immobility time compared to untreated depressed mice. An ERK1/2 inhibitor blocked these ketamine-induced changes, indicating that the ERK/GLUT3 pathway mediates ketamine's antidepressant-like effects on brain energy metabolism.