Abstract Objectives Mindfulness practices mediated by immersive virtual reality (VR) have emerged as a novel mediator to deliver and potentially enhance mindfulness experiences and psychological well-being. Although psycho-technology is widely applied in clinical populations there remains a lack of methodological studies evaluating best practices for delivering such interventions to promote...
Treatment-resistant depression (TRD) affects around 20-30% of people with major depressive disorder. In 2019, esketamine nasal spray was approved for TRD by both the US Food and Drug Administration and the European Medicines Agency. While its clinical efficacy and safety are proven, the mechanisms underlying its antidepressant effect remain unclear. The use of metabolomics may allow...