Determination of Enantiomers of Deschloroketamine and Its Metabolites in Wistar Rat Brains
Journal of Separation Science September 1, 2026 Natalie Paškanová, Vendulka Hrubá, Peter Frühauf et al.
ABSTRACT Deschloroketamine (DXE) is a dissociative new psychoactive substance whose enantiomers and metabolites may exhibit distinct pharmacological and toxicological profiles. Reliable analytical methods enabling the chiral determination of DXE and its metabolites in biological matrices are thus essential. In this study, we evaluated supercritical fluid chromatography coupled to tandem mass...