476. Cryptotanshinone, a natural compound, and its metabolite ameliorate addictive properties of nitrous oxide via modulating D1 receptor and TrkB Pathway in the nucleus accumbens
International Journal of Neuropsychopharmacology September 9, 2026 Z-J Zhang
Abstract Background While nitrous oxide (N2O) abuse has been a growing international public health issue, there is a dearth of effective intervention strategies. Our previous study has demonstrasted that addictive properties of N2O are associated with its regulation of D1 receptor and BDNF pathway in the ventral tegmental area-nucleus accumbens. Aims & Objectives This study aimed to investigate...