Biochemical and behavioral effects of sigma and PCP ligands
Synapse 1988 Patricia C. Contreras, Margarita L. Contreras, Thomas L. O'donohue et al.
Abstract The purpose of this study was to examine the binding and behavioral effects mediated by PCP and sigma receptors in the rat. From the radioreceptor assays, it was possible to characterize two binding sites that interact with PCP and sigma ligands. The two sites, a PCP and sigma receptor, could be differentiated based on drug selectivity and potency. In the behavioral assays, MK‐801,...