Phencyclidine produces changes in NMDA and kainate receptor binding in rat hippocampus over a 48-hour time course.
Synapse (New York, N.Y.) August 1996 X M Gao, C A Tamminga
Phencyclidine (PCP) is a psychotomimetic drug associated with acute and delayed mental effects in normal humans and psychosis exacerbation in already psychotic schizophrenic individuals. We have previously described a dose-sensitive, delayed action of PCP on regional cerebral metabolism in the rat which occurs over 48 hours and a late (24 hour) change in N-methyl-d-aspartate (NMDA) and kainate...