Short and long term changes in NMDA receptor binding in mouse brain following chronic phencyclidine treatment.
Journal of neural transmission (Vienna, Austria : 1996) 2007 K A Newell, K Zavitsanou, X-F Huang
Phencyclidine (PCP) is an antagonist of the NMDA subtype of glutamate receptor. PCP treatment induces psychosis in normal humans, which provides a valuable model of schizophrenia. PCP administration also models some of the symptoms of schizophrenia in experimental animals. NMDA hypofunction has been hypothesized to explain these schizophrenia-like symptoms. Acute or chronic administration of...