THE PREVENTION BY INHIBITORS OF BRAIN PROTEIN SYNTHESIS OF THE HYPERACTIVITY AND HYPERPYREXIA PRODUCED IN RATS BY MONOAMINE OXIDASE INHIBITION AND THE ADMINISTRATION OF L‐TRYPTOPHAN OR 5‐METHOXY‐N,N‐DIMETHYLTRYPTAMINE
Journal of Neurochemistry October 1, 1972 D. G. Grahame‐Smitha
Abstract— In rats treated with a monoamine oxidase inhibitor, (tranylcypromine), L‐ tryptophan produces a stereotyped syndrome of hyperactivity and hyperpyrexia due to an increased rate of brain serotonin (5‐hydroxytryptamine) synthesis. Pretreatment of rats with intraperitoneal injections of cycloheximide, acetoxycycloheximide, emetine and dehydroemetine and of mice with puromycin inhibited...