Role of experience in acquisition and loss of tolerance to the effect of delta-9-THC on spaced responding.
Pharmacology, biochemistry, and behavior September 1976 F J Manning
Albino rats were given extensive training in spaced responding, using a DRL 30 sec schedule of food reinforcement (only lever presses more than 30 sec apart were reinforced). All rats then went 12 days without behavioral testing. During this period half the rats received daily intragastric doses of delta-9-tetrahydrocannabinol (THC) and the rest equal volumes of the THC vehicle. On day 13, some...