Tolerance but No Spontaneous Withdrawal Following Repeated THC Injections in Male and Female Rats
Cannabis and Cannabinoid Research December 1, 2025 Christa M. Hickey, Casey Poling, W. Grimes et al.
Introduction: Tolerance and dependence are known to occur with prolonged cannabis use. Few animal experiments on spontaneous withdrawal from delta-9-tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis, have been conducted. The experiments that have been conducted use extremely high doses and report relatively mild symptoms. The objective of the present experiment was to...