452. Primary neuronal cultures to study neuroplastic effects of hallucinogen drugs
International Journal of Neuropsychopharmacology September 9, 2026 N Nicosia, J Mingardi, G Terribile et al.
Abstract Background Chronic stress is a key risk factor for major depressive disorder (MDD), one of the leading causes of disability worldwide1. Despite available pharmacological therapies, treatment-resistant depression (TRD) remains a clinical challenge. Hallucinogens such as ketamine and serotonergic psychedelics including psilocybin and lysergic acid diethylamide (LSD)2 show rapid...