Paul Maruff

2 papers in the library · 9 citations · publishing 2014-2024

Papers

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Effect of Esketamine Nasal Spray on Cognition in Patients With Treatment-Resistant Depression: Results From Four Phase 3 Studies.

The International Journal of Neuropsychopharmacology November 1, 2024 Randall L. Morrison, Jaskaran Singh, Ella Daly et al. 9 citations

While esketamine is effective in treatment-resistant depression (TRD), detailed information about the effect of esketamine on cognition is relatively scarce. This analysis assessed the effect of short-term (3 double-blind [DB] studies: DB1, DB2, and DB4) or long-term maintenance treatment (DB3) with esketamine nasal spray (ESK) compared with a placebo (PBO) combined with active-comparator, on...

DOI: 10.1093/ijnp/pyae046 Full text Esketamine Cogstate battery test Randomized controlled trials Depression treatment +7

Microdosing of scopolamine as a “cognitive stress test”: Rationale and test of a very low dose in an at‐risk cohort of older adults

Alzheimer s & Dementia March 1, 2014 Peter J. Snyder, Yen Ying Lim, Rachel Schindler et al.

Abstract: Background: Abnormal β‐amyloid (Aβ) is associated with deleterious changes in central acetylcholinergic tone in the very early stages of Alzheimer's disease (AD), which may be unmasked by a cholinergic antagonist. We aimed to establish an optimal “microdose” of scopolamine for the development of a “cognitive stress test.” Methods: Healthy older adults (n = 26, aged 55–75 years) with...

DOI: 10.1016/j.jalz.2014.01.009