Effect of acute administration of ketamine and imipramine on creatine kinase activity in the brain of rats.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) September 2009 Lara C Assis, Gislaine T Rezin, Clarissa M Comim et al.
Clinical findings suggest that ketamine may be used for the treatment of major depression. The present study aimed to compare behavioral effects and brain Creatine kinase activity in specific brain regions after administration of ketamine and imipramine in rats. Rats were acutely given ketamine or imipramine and antidepressant-like activity was assessed by the forced swimming test; Creatine...