Acute administration of ketamine reverses the inhibition of mitochondrial respiratory chain induced by chronic mild stress.
Brain Research Bulletin August 14, 2009 Gislaine T Rezin, Cinara L Gonçalves, Juliana F Daufenbach et al.
Modulation and dysfunction of the glutamatergic system seems to be involved in depression. Recently a renewed interest in the glutamatergic system as a treatment option for major depression emerged by the finding that the glutamate N-methyl-D-aspartate (NMDA) antagonist ketamine leads to a rapid improvement of depressive symptoms. Several works support the hypothesis that metabolism impairment...