Pro‐oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes
British Journal of Pharmacology April 21, 2011 Daniel José Barbosa, João Paulo Capela, Jorge M.A. Oliveira et al. 60 citations
BACKGROUND AND PURPOSE: 3,4-Methylenedioxymethamphetamine (MDMA or 'Ecstasy') is a worldwide major drug of abuse known to elicit neurotoxic effects. The mechanisms underlying the neurotoxic effects of MDMA are not clear at present, but the metabolism of dopamine and 5-HT by monoamine oxidase (MAO), as well as the hepatic biotransformation of MDMA into pro-oxidant reactive metabolites is thought...