Abstract Background Stress is a recognized risk factor for developmental and adult psychiatric disorders. Indeed, stressful events, particularly during the first phases of life, such as trauma, neglect or abuse, have been associated with increased psychiatric risk over the course of a lifetime, although with some sex-differences. Indeed, the biological sex shapes the stress response impacting...
Neurodevelopmental disorders (NDDs) comprise a heterogeneous group of conditions arising from altered brain development and leading to impairments in social, cognitive, emotional, and motor domains. Clinical manifestations are highly variable in severity and symptom profile, reflecting the complex and multifactorial etiology of NDDs. Available treatments are limited to early behavioral...
Ketamine may be a novel pharmacologic approach to enhance resilience and protect against stress-related disorders, but the molecular targets underlying this response remain to be fully characterized. The multifunctional protein p11 is crucial in the pathophysiology of depression and antidepressant responses. However, it is still unclear whether p11 plays a role in the pro-resilience effects...