The discovery that a single subanesthetic dose of (R,S)-ketamine induces rapid and long-lasting antidepressant effects by a completely different mechanism represents one of the most substantial break-throughs in depression pharmacotherapy. The recent study in Nature by Yue and colleagues represents a signi fi cant conceptual and technical advance by identifying NMDA-independent transient...
Molecular PsychiatryJune 1, 2025Anderson Camargo, Anna Nilsson, Reza Shariatgorji et al.5 citations
Ketamine may be a novel pharmacologic approach to enhance resilience and protect against stress-related disorders, but the molecular targets underlying this response remain to be fully characterized. The multifunctional protein p11 is crucial in the pathophysiology of depression and antidepressant responses. However, it is still unclear whether p11 plays a role in the pro-resilience effects...