Rapid development of tolerance to sub-anaesthetic dose of ketamine: an oculomotor study in macaque monkeys.
Psychopharmacology May 2010 Pierre Pouget, Nicolas Wattiez, Sophie Rivaud-Péchoux et al.
Ketamine, a non-competitive N-methyl-D: -aspartic acid antagonist, has been widely used for anaesthetic purposes. At sub-anaesthetic dosage, it induces a dissociative state similar to schizophrenia. The discovery of this effect on dissociative state has led to its use as a pharmacological model of schizophrenia and has also been responsible for its illegal use as a recreational drug. Whereas...