Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation.
Science (New York, N.Y.) September 3, 2026 Mario Heles, Lilach Pasvolsky, Hinduja Sathishkumar et al.
Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling, often irreversible toxicity that affects millions of patients, limits life-saving cancer therapy, and lacks proven treatment. In this work, we show that as little as two doses of psilocybin before chemotherapy durably prevented the onset of CIPN across platinum- and taxane-based models, including repeated chemotherapy cycles,...