Psilocybin asymmetrically modulates outcome-based choice and cortical processing under uncertainty.
bioRxiv : the preprint server for biology August 13, 2026 David S Jacobs, Alejandro Torrado Pacheco, Randall Olson et al. preprint
Emerging clinical research with psilocybin highlights the value of the psychedelic experience on successful treatment of a multitude of psychiatric disorders. While the psychedelic trip or clinical support procedures cannot be modeled in rodents, neural processes critical to meta-learning and flexible modification of previously learned strategies can be quantified during psilocybin exposure....