Trial of Subcutaneous Ketamine for Psychotic Depression in an Older Adult With Comorbid Physical Illness: A Case Report
BJPsych Open June 1, 2026 Roshan Ganeshan, Tharun Zacharia
Aims: Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist used for anaesthesia and analgesia, with increasing interest in its rapid antidepressant effects. This case evaluates the feasibility, tolerability and clinical response to subcutaneous ketamine in a medically frail older adult with psychotic depression, hypothesising that ketamine would rapidly improve engagement and...