Psychedelic MedicineJuly 24, 2026Matthew C. Company, Dylan J. Lifshitz, M. Farris Sawaya et al.
This narrative review traces how the scientific understanding of psychedelics has intersected with “reward processing” from before the Controlled Substances Act (CSA) era to the present, emphasizing how cultural and regulatory climates shaped what was viewed as an acceptable research question. Reward processing is treated as a family of partially overlapping phenomena: (1) reward-linked...
Brain StimulationMay 21, 2026Lucas Dwiel, Mackenzi L. Prina, Elise Bragg et al.
A leading theory for how psychedelics are able to produce robust clinical improvement and preclinical behavioral changes is that psychedelics act through neuroplastic mechanisms to induce lasting structural and functional alterations in neural circuits. However, psychedelics produce these effects across wide swaths of the brain. Based on our prior work, we hypothesized that engaging a specific...