Classic Psychedelics for Treating Chronic Pain: Mechanism and Clinical Translation
Molecules July 27, 2026 Hongyu Chen, Bowen Ke, Ruotian Jiang
Chronic pain is a complex disorder of central nervous system maladaptation, perpetuated not only by ascending nociceptive transmission but also by entrenched prior expectations. Conventional analgesics typically fail to reverse this cognitive rigidity and the ensuing pathological cycles. Classic psychedelics, however, are emerging as a promising avenue to help address this therapeutic impasse....