The Emergence of Isotryptamine Analogs as Novel Serotonergic Agents with Psychotherapeutic Potential
ACS Pharmacology & Translational Science August 18, 2026 Richard A. Glennon, Maƚgorzata Dukat
Abstract Isotryptamines, or 2-(1-indolyl)ethylamines, are positional or geometric isomers of tryptamines where the aminoethyl substituent has been relocated from the indole 3-position to the N1-position. Early studies with these types of agents relied on peripheral tissue assays for examination of their serotonin (5-hydroxytryptamine; 5-HT) receptor affinities to investigate structure–affinity...