C. C. Liew

Lysergic Acid Diethylamide: Effect on Histone Acetylation in Rabbit Brain

Science June 13, 1975 Ian R. Brown, C. C. Liew

Lysergic acid diethylamide increased acetylation of histones in rabbit cerebral hemispheres and midbrain 30 minutes after intravenous administration of the drug at doses of 10 and 100 micrograms per kilogram of body weight. Evidence for the stimulation of acetylation in individual histone bands was obtained after separation by electrophoresis on polyacrylamide gels.