Effects of Cannabis on Glutamatergic Neurotransmission: The Interplay between Cannabinoids and Glutamate.
Cells June 29, 2024 Kawsar U Chowdhury, Madison Elizabeth Holden, Miles T Wiley et al.
This review examines how cannabis and its derivatives alter glutamatergic neurotransmission, affecting memory. Acute cannabis exposure typically inhibits glutamate release, while chronic use tends to increase it. Postsynaptic changes, including glutamate receptor expression and downstream signaling, are more complex. Factors such as dosage, sex, age, and frequency of use influence these effects. The review covers current research on glutamate-cannabis interactions and identifies future research directions needed to understand cannabis-related health and neurological effects.