Ketamine-induced antidepressant like effects in mice: A possible involvement of cannabinoid system.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie April 1, 2019 Fatemeh Khakpai, Mohaddeseh Ebrahimi-Ghiri, Sakineh Alijanpour et al.
The purpose of this study was to explore the possible interaction between ketamine and cannabinoid system in the modulation of depression-related responses using the forced swimming test (FST), tail suspension test (TST) and open-field test (OFT) in mice. Our results revealed that intra-peritoneal (i.p.) injection of ketamine (5 and 10 mg/kg), a non-competitive NMDA antagonist, dose-dependently...