Ketamine-induced antidepressant like effects in mice: A possible involvement of cannabinoid system.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie April 1, 2019 Fatemeh Khakpai, Mohaddeseh Ebrahimi-Ghiri, Sakineh Alijanpour et al.
Ketamine, an NMDA antagonist, produced antidepressant-like effects in mice in the forced swimming test at doses of 5 and 10 mg/kg. Both CB1 and CB2 receptor drugs—ACPA (1 mg/kg), AM251 (1 mg/kg), GP1a (2 mg/kg), and AM630 (0.5 mg/kg)—also showed antidepressant action. Combining ineffective doses of ketamine with cannabinoid receptor antagonists resulted in antidepressant-like effects. None of the drug doses altered locomotor activity in the open-field test. The findings suggest a possible interaction between ketamine and the cannabinoid system in modulating depression-related behavior.