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Benjamin C. Nephew

2 papers in the library · 3 citations · publishing 2024

Papers

Race-Based Differences in the Response to a Mindfulness Based Integrative Medical Group Visit Intervention for Chronic Pain.

Global advances in integrative medicine and health January 1, 2024 Angela C. Incollingo Rodriguez, Benjamin C. Nephew, Justin J Polcari et al. 3 citations

African American/Black participants with chronic pain and depression who took part in Integrative Medical Group Visits (IMGV) showed reduced pain severity from baseline to 9 weeks, a change not seen in White participants. However, White participants experienced reduced pain severity from 9 to 21 weeks, while African American/Black participants showed no significant change during that later period. At baseline, African American/Black participants had higher pain severity and differed in age, work status, and comorbidities. The findings suggest race-based differences in response to mindfulness-based integrative treatments, highlighting the need for further investigation into how such heterogeneity relates to health disparities.

Machine learning based phenotyping of the response to mindfulness for chronic low back pain

Akshit Soota, Angela C. Incollingo Rodriguez, Benjamin C. Nephew et al. preprint

Machine learning applied to data from a clinical trial of mindfulness for chronic low back pain identified distinct phenotypes that predict who will respond to the intervention. Among 132 participants in the mindfulness arm, 49 were responders and 83 were non-responders. The top three responder phenotypes correctly identified 26 of the 49 responders with 92-100% precision, and the top three non-responder phenotypes identified 36 of the 83 non-responders with 100% precision. These results may help clinicians and patients decide whether mindfulness is likely to be beneficial, improving treatment efficiency and outcomes.