Nicole L Zabik

2 papers in the library · publishing 2020-2026

Papers

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Dose-dependent effect of acute THC on extinction memory recall and fear renewal: a randomized, double-blind, placebo-controlled study.

Psychopharmacology February 1, 2026 Nicole L Zabik, Allesandra Iadipaolo, Craig A Peters et al.

Prior work from our lab and others demonstrates that the endocannabinoid system is a promising avenue for improving fear memory deficits in posttraumatic stress disorder (PTSD). Specifically, 7.5 mg of delta-9-tetrahydrocannabinol (THC) decreases fear responding in healthy adults and increases prefrontal cortex activation during extinction learning and fear renewal in adults with PTSD. The...

DOI: 10.1007/s00213-024-06702-w Full text PTSD Anterior cingulate cortex Cannabinoids Fear conditioning +2

Cannabinoid modulation of corticolimbic activation to threat in trauma-exposed adults: a preliminary study.

Psychopharmacology June 2020 Christine A Rabinak, Ashley Blanchette, Nicole L Zabik et al.

Excessive fear and anxiety, coupled with corticolimbic dysfunction, are core features of stress- and trauma-related psychopathology, such as posttraumatic stress disorder (PTSD). Interestingly, low doses of ∆9-tetrahydrocannabinol (THC) can produce anxiolytic effects, reduce threat-related amygdala activation, and enhance functional coupling between the amygdala and medial prefrontal cortex and...

DOI: 10.1007/s00213-020-05499-8 Full text PTSD Amygdala Cannabinoid Prefrontal cortex +1