0834 Hypnagogic/Hypnopompic Hallucination Types Among Participants with Narcolepsy Type 1 from the Phase 3 REST-ON Trial
Sleep May 1, 2025 Michael J. Thorpy, Jennifer M Mundt, Sally Ibrahim et al.
In people with narcolepsy type 1, once-nightly sodium oxybate reduced the number of hypnagogic/hypnopompic hallucinations (HH) per day compared with placebo over 13 weeks. At baseline, participants averaged about 0.6 HH events per day. By week 13, the sodium oxybate group showed a mean reduction of 0.29 events per day, while the placebo group showed a reduction of 0.24 events per day. Among 12,455 total HH events, 62% were hypnagogic (occurring at sleep onset) and 38% were hypnopompic (occurring upon waking). The most common hallucination types were feeling that shadows or objects are moving or distorting and feeling another presence in the room. Approximately half as many events of feeling attacked, flying, or falling into a hole were reported with sodium oxybate versus placebo.