Kasper Recourt

2 papers in the library · 1 citation · publishing 2023-2025

Papers

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Ketamine effects on resting state functional brain connectivity in major depressive disorder patients: a hypothesis-driven analysis based on a network model of depression.

Frontiers in Neuroscience 2025 Kasper Recourt, Joop van Gerven, Nadieh Drenth et al. 1 citation

Ketamine demonstrates robust and rapidly occurring antidepressant effects in patients with difficult-to-treat major depressive disorder. Ketamine's antidepressant effects and its impact on functional networks in non-resistant forms of major depressive disorder are expected to provide valuable insight into ketamine's mechanism of action related to depression. This study employs an existing...

DOI: 10.3389/fnins.2025.1531375 Full text Major depressive disorder Nmda receptor Functional MRI Glutamatergic modulator +6

Item response theory in early phase clinical trials: Utilization of a reference model to analyze the Montgomery-Åsberg Depression Rating Scale.

CPT: Pharmacometrics & Systems Pharmacology October 2023 Marije E. Otto, Kirsten R Bergmann, Marieke L De Kam et al.

In clinical trials, Montgomery-Åsberg Depression Rating Scale (MADRS) questionnaire data are added up to total scores before analysis, assuming equal contribution of each separate question. Item Response Theory (IRT)-based analysis avoids this by using individual question responses to determine the latent variable (ψ), which represents a measure of depression severity. However, utilization of...

DOI: 10.1002/psp4.13018 Full text