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Marieke L De Kam

4 papers in the library · 24 citations · publishing 2024-2026

Papers

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Safety, pharmacokinetics, and pharmacodynamics of intravenously administered deuterated N,N-dimethyltryptamine (CYB004) in healthy volunteers.

Journal of psychopharmacology (Oxford, England) September 3, 2026 Katelijne V Van der Heijden, Gabriel E Jacobs, Ellen H James et al.

Serotonergic psychedelics, such as N,N-dimethyltryptamine (DMT), have shown therapeutic potential in various psychiatric disorders. However, DMT demonstrates pharmacokinetic (PK) variability and a short half-life. This exploratory study investigated the PK, pharmacodynamic (PD), and safety profile of CYB004, a deuterated DMT analogue, following intravenous administration in healthy volunteers....

DOI: 10.1177/02698811261478616 (opens in new tab) Full text (opens in new tab) DMT Deuteration Pharmacodynamics Pharmacokinetics +1

Pharmacokinetics, pharmacodynamics and safety of N,N -dimethyltryptamine administered intravenously in healthy smoking and non-smoking volunteers

Journal of Psychopharmacology August 31, 2026 Katelijne V. van der Heijden, Soma Makai‐bölöni, Amir Inamdar et al.

BACKGROUND: -dimethyltryptamine (DMT) might have therapeutic effects in various psychiatric disorders. AIMS: Prior to exploring this clinical potential, it is essential to determine an optimal administration regimen for DMT, explore the relationship between its pharmacokinetics (PK) and pharmacodynamics and identify potential sources of pharmacokinetic variability. METHODS: Therefore, DMT was...

DOI: 10.1177/02698811261473451 (opens in new tab)

Safety, Pharmacokinetics, and Pharmacodynamics of a 6-h N,N-Dimethyltryptamine (DMT) Infusion in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Trial.

Clinical and Translational Science May 1, 2025 Katelijne V. van der Heijden, Rob G J A Zuiker, Marije E. Otto et al. 7 citations

The serotonergic psychedelic N,N-dimethyltryptamine (DMT) presumably stimulates neuroplasticity in vitro and in vivo, by which it may exert neuroprotective effects during acute ischemic stroke. Since neuroplasticity has been implicated in the mechanism of action of rehabilitative therapy in stroke recovery, a pharmacological augmentation strategy facilitating neuroplasticity could be...

DOI: 10.1111/cts.70234 (opens in new tab) Full text (opens in new tab) N-dimethyltryptamine N,N‐Dimethyltryptamine Healthy volunteers Intravenousinfusion +10

Cannabidiol Increases Psychotropic Effects and Plasma Concentrations of Δ9-Tetrahydrocannabinol Without Improving Its Analgesic Properties.

Clinical pharmacology and therapeutics November 1, 2024 Andriy A Gorbenko, Jules A A C Heuberger, Linda E. Klumpers et al. 17 citations

Cannabidiol (CBD), the main non-intoxicating compound in cannabis, has been hypothesized to reduce the adverse effects of Δ9-tetrahydrocannabinol (THC), the main psychoactive and analgesic component of cannabis. This clinical trial investigated the hypothesis that CBD counteracts the adverse effects of THC and thereby potentially improves the tolerability of cannabis as an analgesic. A...

DOI: 10.1002/cpt.3381 (opens in new tab) Full text (opens in new tab)