NeuroimageMarch 25, 2026Fabrizio Parente, Tiziana Pedale, Ilenia Salsano et al.
The Default Mode Network (DMN) is a large-scale intrinsic brain network critically involved in internally oriented cognition, including autobiographical memory. Core DMN regions such as the hippocampus and medial prefrontal cortex are central to memory retrieval, schema construction and self-referential processing. Individuals with Highly Superior Autobiographical Memory (HSAM) provide a unique...
How the brain generates conscious experiences remains profoundly mysterious. Pharmacological interventions that alter the state of consciousness have been proposed as a tool to investigate the neural mechanisms of consciousness. However, we have recently demonstrated that the sedative Propofol influences both conscious and unconscious neural processing. Altered arousal, and other...
Being conscious is a profound aspect of human existence, and understanding its function and its inception is considered one of the truly grand scientific challenges. However, the nature of consciousness remains enigmatic, to a large part because “being conscious” can refer to both the content (phenomenology) and the level (arousal) of consciousness, and how these different aspects are related...